Eilyad Issabeagloo, Ahmad Asghari, Mohammad Taghizadieh and Parviz Kermanizadeh
Ketamine is one of agents blockade receptors influenced glutamate (as a potent excitatory amino acid of CNS). This drug has some side effects such as hypertension, histamine releasing effects, hallucination, hyper salivation (especially with oral administration) and etc. Clonazepam is a benzodiazepine that can pass trough blood-brain barrier and causes CNS suppression. Then it seems that co administration of Clonazepam and ketamine cause more effective & deep CNS depression effects and also alleviate some of ketamine adverse effects such as hallucination. The aim of this study was evaluation of ketamine and Clonazepam CNS suppressions effects in the manner of single and together in cat. Ten free roaming male & mature cats received drugs [ketamine (20, 40, 80mg/kg) & Clonazepam (1.5, 3, 4.5 mg/kg)] first in mixture of milk (40ml) or meat (30g) or oral spray rout. In 2nd stage they received concomitant doses of Clonazepam & ketamine by the method mentioned above. Each animal was observed continually by educated observer for CNS depression as graded on the behavioral scales. Almost all of the animals rejected receiving drugs in mixture of milk and meat. So oral rout used for administration of drugs. Clonazepam & ketamine showed dose dependent effects in different administered doses. Concomitant use of Clonazepam with ketamine improved depth and duration of ketamine's CNS depression effects. So results of this study showed this fact that administration of ketamine & Clonazepam in mixture of milk & meat is not a suitable method in cats. Also Clonazepam in mentioned doses caused a weak suppression of CNS. But a strong and long time CNS depression (anaesthesia) is achieved when ketamine sprayed in mouth. These Symptoms are considered significant in co administration of these two drugs.
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