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Antibiomania: Clarithromycin-Induced Mania?

Radkin Honzak

The authors present a case of antibiomania in a 55-year-old woman with a previous history of borderline personality disorder, anorexia nervosa, and longlasting anxious and depressive symptomatology associated with her husband´s serious illness. The switch to mania occured after two 500mg doses of clarithromycin – the third antibiotic she had been administered in four months. Manic symptoms were so severe that involuntary hospitalization was required. Signs of mania disappeared within a week in the psychiatric ward. The authors submit the hypothesis that the pathogenetic pathway of this sudden reversal into mania may have been triggered by clarithromycin-induced dysmicrobia of the intestinal flora, which crossed into the CNS through either a leaky gut or by direct stimulation of the nervus vagus.

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