Ehiaghe Friday Alfred, Ihim Augustine, Osakue Omoyemen Nosahkare, Onah Ejike Christian, Ehiaghe Imuetiyan Joy, Erhunmwunse Raphael Usiosefe, Oyeyemi Adekunle Wahab, Akinshipe Benson Olu
Background: Moderate alcohol consumption had been associated with a lower relative threat of chronic heart disease. The precise mechanisms of this lower risk are not always clear.
Methods: Thus, this study was designed to determine the inflammatory cytokines, myocardial, and homeostatic responses using the levels of circulating interleukin 1β, IL-10, serum C-reactive protein, absolute lymphocyte counts, creatinine kinase-M, troponin-I and values of activated partial thromboplastin time and prothrombin time. The pre and post experimental design consists of 50 consented apparently healthy young male with an average age of 28.3 ± 3.0 years and body mass index of 24.7 ± 1.8 (Kg/m2) who were randomly selected from residents and staff of Nnamdi Azikiwe University, Nnewi environ. The blood samples collected in EDTA (1.5 mg/ml) were used for absolute white blood cell count and total white blood cell count using Sysmex® Automated Hematology Analyzer. Blood anticoagulated with 0.109 M trisodium citrate (9: 1 v/v) were used for the measurement of activated partial thromboplastin time and prothrombin time. Serum interleukin 1β, IL-10, serum C-reactive protein, creatinine kinase-M and troponin-I were evaluated using enzyme-linked immunosorbent assay method. All numerical results were analyzed with student’s t-test using SPSS version 20.0 statistical program. P<0.05 were considered significant.
Results: The levels of IL-1β, IL-10 and CRP were significantly lower at one month post alcohol consumption when compared with pre stage while the levels of TLC, AGC, ALC, CK-MB, TI, PLT, APTT and PT shows no significant difference at one month post alcohol consumption when compared with pre stage.
Conclusion: One month alcohol consumption tends to switch the cytokine pattern toward the anti-inflammatory pattern. Thus, it is extremely important that alcohol use be constrained to moderate consumption.
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