Roychowdhury Santanu, Singh Hussandeep, Deora Gaurav and Sharma Sanchita
The present investigation concerns with the development, optimization and evaluation of an enteric coated tablets of Erythromycin stearate. Tablets were prepared by wet granulation method. Enteric coating of Erythromycin stearate tablets were done using two hydrophilic polymers like ethyl cellulose and pectin by multivariate ANOVA method by alternating the 2 variables X and Y in rows and columns. Polyethylene glycol was used as a plasticizer while Isopropyl alcohol & water was incorporated as a solvent. The effects of polymers and Isopropyl alcohol as a binder on drug release profile, gastro-resistant properties and matrix integrity of tablet were investigated. Developed formulations were evaluated for their physical characteristics, drug content, disintegration time, friability, hardness, thickness, swelling index, weight variation, In vitro drug release profile etc. On the basis of various physical characteristics parameters, it was found that all the formulations shows good result. On comparative kinetic modeling study such as (Zero order, First order, Higuchi model and Korsmeyer-Peppas) it was found that all the formulations follow Higuchi model and correlation coefficient (R2) values were nearer to unity. Among those formulations, F4 showed R2 value of Higuchi model more near as compared to the other formulation.
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