नेत्र एवं मोतियाबिंद सर्जरी जर्नल खुला एक्सेस

अमूर्त

Stem cell transplantation for vision

Rajat Jain

A 28-year female presented with progressive decrease in vision and pannus formation in both eyes for the past 10 years. There was no history of any past surgery, drug reaction or injury. The disease progression was such that right eye was lost five years back. At presentation, right eye was phthisical. Vision in the left eye was hand movements close to face with total limbal stem cell deficiency, Inferolateral symblepharon, and a normal posterior segment on B Scan. Options of keratoprosthesis were discussed. We performed allogenic limbal stem cell transplantation wherein limbal tissue was taken from the mother. On the patient’s eye, pannus was excised, amniotic membrane was transplanted sutureless all over the cornea and upto three mm beyond. Limbal biopsy was cut into small pieces and spread over the cornea in circular fashion. Lateral tarsorrhaphy was done at the end. After three years follow-up, the patient was on systemic immune suppression and maintained a vision of 6/18. Treatments for many disorders that cause vision loss square measure troublesome or not nonetheless attainable. Specialised cells within the eye serve specific functions to focus light-weight and switch what’s being seen into signals sent to the brain. the attention contains many forms of stem cells that perpetually replace specialised cell that become tired or broken. Holoclar is presently the sole clinically approved somatic cell treatment for the attention. This treatment restores vision to patients with broken corneas (the clear outmost a part of the attention) by transplant lab-grown limbal stem cells into areas of the eye lacking these cells. Holoclar® solely works if folks have some limbal stem cells left in their eyes for clinical labs to grow. New ways of creating limbal cells with pluripotent stem cells square measure being developed for folks with none limbal stem cells left. Researchers square measure finding out however transplants of retinal pigment animal tissue cells created with pluripotent stem cells may stop vision loss in patients with diseases like age-related devolution. Researchers also are mistreatment stem cells to check many various aspects of the attention, from however the attention is created to what causes eye diseases and the way to treat them.